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This study focuses on classification of chromosomes into 23 types, a step towards fully automatic karyotyping. This study proposes a convolutional neural network (CNN) based deep learning network to automatically classify chromosomes. The proposed method was trained and tested on a dataset containing 10304 chromosome images, and was further tested on a dataset containing 4830 chromosomes. The proposed method achieved an accuracy of 92.5%, outperforming three other methods appeared in the literature. To investigate how applicable the proposed method is to the doctors, a metric named proportion of well classified karyotype was also designed. An result of 91.3% was achieved on this metric, indicating that the proposed classification method could be used to aid doctors in genetic disorder diagnosis.
- SVM classifier
- K means clustering
- High Computational load
- Poor discriminatory power
- Less accuracy in classification
- A CNN passes an image through the network layers and outputs a final class. The network can have tens or hundreds of layers, with each layer learning to detect different features. Filters are applied to each training image at different resolutions, and the output of each convolved image is used as the input to the next layer. The filters can start as very simple features, such as brightness and edges, and increase in complexity to features that uniquely define the object as the layers progress.
CNNs, like neural networks, are made up of neurons with learnable weights and biases. Each neuron receives several inputs, takes a weighted sum over them, pass it through an activation function and responds with an output. The whole network has a loss function and all the tips and tricks that we developed for neural networks still apply on CNN?
PYTHON IDLE ABOVE 3.0
SYSTEM ABOVE 4 GB RAM
In this study, an automatic-classification method based on CNNs was proposed. The model extracts chromosome images from karyotype and output their classes. Compared with three other methods and deep learning algorithms, our method achieved a better accuracy. Our experiment also shows that our method is applicable in real life tasks.
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